How ZULRESSO is thought to work.

The mechanism of action of brexanolone in the treatment of postpartum depression is not fully understood, but is thought to be related to its positive allosteric modulation of GABAA receptors.1

Brexanolone, a neuroactive steroid gamma-aminobutyric acid (GABA)A receptor positive modulator

For illustrative purposes only.

Brexanolone, a neuroactive steroid gamma-aminobutyric acid (GABA)A receptor positive modulator

ZULRESSO contains brexanolone, a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator.1

ZULRESSO works differently1

ZULRESSO does not directly affect monoaminergic systems. Positive allosteric modulators of the GABAA receptor enhance the response of naturally occurring GABA by binding to the receptor and increasing neuronal inhibition by GABA.1-3

Pharmacodynamics1

Brexanolone potentiated GABA-mediated currents from recombinant human GABAA receptors in mammalian cells expressing α1β2γ2 receptor subunits, α4β3δ receptor subunits, and α6β3δ receptor subunits.1

For illustrative purposes only.